L-838,417 is a partial agonist at α2, α3 and α5 subunits and an antagonist at ... of subtype-selective GABA A receptor modulators as a potential new class of drugs for chronic pain.

However, the development of antireflux compounds during the past 5 years (mainly GABA B agonists and mGluR5-negative allosteric modulators) has been disappointing as all have been abandoned ...